Deciphering Alzheimer Disease

Deciphering Alzheimer disease.

Alzheimer disease represents an insidious impairment of intellect and emotional well-being. However, recent advances in biochemical pathology and human genetics offer promise that effective therapeutic agents may soon be developed.

Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.

P 133: Neuroinflammation in Alzheimer ’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia. Almost 47 million people suffer from dementia worldwide. AD accounts for approximately 60%–80% of all dementia cases. Three major pathologies characterize the disease: senile plaques, neurofibrillary tangles and inflammation. We review the literature on events contributing to the inflammat...

Alzheimer Disease

As the population ages, Alzheimer disease is becoming more of a medical, social and public health concern. It is a dementing disorder that causes severe and permanent loss of intellectual function. Patients with Alzheimer disease begin having forgetfulness, then progress to having irreversible loss of memory (including the memory of their own families) and other previously well-learned skills. ...

Alzheimer ’ s disease 49 4 Alzheimer ’ s disease

(a) The types of population vary enormously in parameters such as place of residence (e.g. community versus hospital-based samples) and age range (as dementia is much more common in the very elderly, a sample stratified towards the upper age ranges will contain numerically more cases). (b) The diagnostic procedures vary, some involve personal examination by trained staff, others rely on second-...